Midlife Risk Factors and Healthy Survival in Men

In JAMA, today is a report of a study to test whether midlife biological, lifestyle, and sociodemographic risk factors are associated with overall survival and exceptional survival. High grip strength and avoidance of overweight, hyperglycemia, hypertension, smoking, and excessive alcohol consumption were associated with both overall and exceptional survival. In addition, high education and avoidance of hypertriglyceridemia were associated with exceptional survival, and lack of a marital partner was associated with mortality before age 85 years. Risk factor models based on cumulative risk factors (survival risk score) suggest that the probability of survival to oldest age is as high as 69% with no risk factors and as low as 22% with 6 or more risk factors.