In an article in this week's JAMA [JAMA. 2008;299(21):2543-2549. ] the authors report that the majority of "diabetes studies fail to track the results patients care about the most, including pain, ability to function, and survival," according to lead author Victor M. Montori, M.D., who conducted an analysis "of clinical trials planned or under way," he and "found that 77 percent were designed to report on levels of glucose, or sugar, in the blood, cholesterol levels, kidney function, and other laboratory tests." In contrast, the researchers found that "stroke, myocardial infarction, amputation, visual disturbance or blindness, end-stage renal disease, hypoglycemic events, delayed wound healing, infection, pain, and functional status," were most important to diabetes patients, Comment: This is the problem with Academic studies that rarely reflect the real world. This phenomenon of performing research on the small fraction of patients who enter teaching hospitals has been criticized for more than 40 years, without a response from most Academics. The first report was published by Kerr White MD as "The Ecology of Public Health" NEJM 1961:263: 18, 885 - 892. Much more research needs to be performed at primary care sites, not in teaching centers.