'Longevity Gene' Common Among People Living To 100 Years Old And Beyond

ScienceDaily (Feb. 4, 2009) — A variation in the gene FOXO3A has a positive effect on the life expectancy of humans, and is found much more often in people living to 100 and beyond – moreover, this appears to be true worldwide. Research on French, German and Japanse centenarians have shown increased frequency of this gene in centenarians. FOXO3A is of great interest for genetic research on ageing, since it was reported in the 1990s that the gene was connected with ageing processes in worms and flies. It is because of those observations that the Kiel research group at the Institute of Clinical Molecular Biology has been working for a long time on variations of this gene in humans.